Microsoft posted on their MDOP blog that App-V 4.6 RTM'd on Friday.  Oh and there was something or other posted about Med-V.  So back to App-V ;)   4.6 RTM includes support for 64-bit Windows platforms which means you can get a functional deployment of Windows 7 64-bit and more importantly you can begin your projects to rollout 2008 R2 with a supported 64-bit App-V client.  Now all we need is a supported release of Citrix XenApp for 2008 R2 and we're golden.  Read more about the App-V 4.6 RTM here.